Mini Review

Lipid-induced cardiovascular diseases

Sumeet Manandhar, Sujin Ju, Dong-Hyun Choi and Heesang Song*

Published: 23 November, 2017 | Volume 2 - Issue 1 | Pages: 085-094

Cardiovascular diseases are the leading cause of death worldwide. There are many evidences that the dysfunctioning lipotoxicity is the one of major factors of cardiovascular diseases such as, atherosclerosis, hypertension, and coronary heart disease. Obesity and diabetes increase circulating lipids that are likely with more generation of toxic intermediates, which leading to the complications associated with cardiovascular diseases. Indeed, lipotoxicity is a metabolic syndrome caused by abnormal lipid accumulation, which leads to cellular dysfunction and necrosis. Here we review the factors that induced pathogenesis of cardiovascular diseases by lipid accumulation and the mechanisms underlying the lipotoxicity.

Read Full Article HTML DOI: 10.29328/journal.jccm.1001018 Cite this Article Read Full Article PDF


Lipotoxicity; Cardiovascular diseases; Pathogenesis


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