Covid-19 New

More Info

Open access Aims and Scope Instructions Editorial Guidelines Licensing Copyright

Author's satisfaction with

  • Friendly and hassle-free publication process
  • Less production time of articles
  • Constructive peer-review
  • Enhancing journal reputation
  • Regular feedback system
  • Quick response to authors' queries

Read More

Recently Viewed

Room temperature organic superconductor compound prediction Probing nuclear equation of state with the cdm3y version of Research into the fundamental building block of quantum theo Strongyloides stercoralis and glomerular diseases: A case re Fluctuation of serum creatinine: preoperative and postoperat

Read More

Most Viewed

Feasibility study of magnetic sensing for detecting single-n Physical activity can change the physiological and psycholog A case report of Multi System Atrophy (MSA) with cross over An algorithm to safely manage oral food challenge in an offi Food applications of Aloe species: A review

Read More

Open Journals

Clinical Images

For Authors Guide For Authors Benefits For Authors Article Processing Charge How To Write a Scientific Paper How To Write a Review Article Short Communication
For Reviewers Benefits For Reviewers How To Review Thanks To Reviewers
For Editors Benefits For Editors Thanks To Editors

Abstract

Review Article

The mechanisms of cardiac myopathies, a kinetics approach: Leading review

Gerry A Smith*

Published: 16 July, 2020 | Volume 5 - Issue 2 | Pages: 141-152

The normal adult heart is a well maintained machine that has a mechanism for growth replacement of the sarcomere that is lost by natural degeneration. This process ensures the heart has the strength of contraction to function correctly giving blood supply to the whole body. Some of the force of contraction of the sarcomere is transmitted to its major protein titin where its strength results in unfolding of a flexible section and release of a growth stimulant. The origin of all the cardiomyopathies can be traced to errors in this system resulting from mutations in a wide variety of the sarcomeric proteins. Too much or chronic tension transfer to titin giving increased growth resulting in hypertrophic cardiomyopathy (HCM) and too little leading to muscle wastage, dilated cardiomyopathy (DCM). HCM can ultimately lead to sudden cardiac death and DCM to heart failure. In this paper I show (1) a collection of the tension/ATPase calcium dependencies of cardiac myofibrils that define the mechanism of Ca2+ cooperativity. (2) I then reintroduce the stress/strain relationship to cardiomyopathies. (3) I then review the cardiomyopathy literature that contains similar Ca2+ dependency data to throw light on the mechanisms involved in generation of the types of myopathies from the mutations involved. In the review of cardiomyopathy there are two sections on mutations, the first dealing with those disrupting the Ca2+ cooperativity, i.e. the Hill coefficient of activation, leading to incomplete relaxation in diastole, chronic tension, and increased growth. Secondly dealing with those where the Ca2+ cooperativity is not affected giving either increased or decreased tension transfer to titin and changes in sarcomere growth. 

Read Full Article HTML DOI: 10.29328/journal.jccm.1001101 Cite this Article Read Full Article PDF

Keywords:

Cardiac myosin binding cardiac protein-C (cMyBP-C); Cardiac troponin-I (cTnI); Cardiac troponin T (cTnT); Cardiac troponin C (cTnC); Calcium dependency; Magnesium ATP (MgATP); Myofilaments; ATPase; Contraction; Ca2+ cooperativity; Hill coefficient (nH); Sarcomere growth and loss

References

  1. Holroyde MJ, Robertson SP, Johnson JD, Solaro RJ, Potter JD. The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase. J Biol Chem. 1980; 25; 255: 11688–11693. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6449512
  2. Smith GA, Dixon HB, Kirschenlohr HL, Grace AA, Metcalfe JC, Vandenberg JI. Ca2+ buffering in the heart: Ca2+ binding to and activation of cardiac myofibrils. Biochem J. 2000; 346 (Pt 2): 393–402. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220865/
  3. Morimoto S and Ohtsuki I. Ca2+ binding to cardiac troponin C in the myofilament lattice and its relation to the myofibrillar ATPase activity. Eur J Biochem. 1994; 226: 597-602. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8001574
  4. Smith GA, Vandenberg JI, Freestone NS and Dixon HBF,The effect of Mg2+ on cardiac muscle function: is CaATP the substrate for priming myofibril cross-bridge formation and Ca2+ re-uptake by the sarcoplasmic reticulum? B J. 2001; 354: 539-551. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221685/
  5. Donaldson SK, Best PM, Kerrick GL. Characterization of the effects of Mg2+ on Ca2+- and Sr2+-activated tension generation of skinned rat cardiac fibers. J Gen Physiol. 1978; 71: 645–655. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/97362
  6. Hofmann PA, Hartzell HC, Moss RL. Alterations in Ca2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers. J Gen Physiol. 1991; 97: 1141–1163. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1678777
  7. Kampourakis T, Yan Z, Gautel M, Sun YB and Irving M. Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells PNAS. 2014; 111: 18763-18768. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25512492
  8. Smith GA. Calcium, actomyosin kinetics, myosin binding protein-c and hypertrophic cardiomyopathy. J Integr Cardiol. 2019; 5: 1-2.
  9. Teekakirikul P, Zhu W, Huang HC, Fung E. Hypertrophic Cardiomyopathy: An Overview of Genetics and Management. Biomolecules. 2019; 16 9: 878. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31888115
  10. van Dijk SJ, Dooijes D, dos Remedios C, Michels M , Lamers JMJ, et al. Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and Cardiomyocyte Dysfunction. Circulation. 2009; 119: 1473–1483. PubMed:https://pubmed.ncbi.nlm.nih.gov/19273718/
  11. Doh CY, Li J, Mamidi R, Stelzer JE. The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019; 1865: 661-677. PubMed:
  12. Parbhudayal RY, Garra AR, Götte MJW, Michels M, Pei J, et al. Variable Cardiac Myosin Binding protein-C Expression in the Myofilaments Due to MYBPC3 Mutations in Hypertrophic Cardiomyopathy. J Mol Cell Cardiol. 2018; 123: 59-63. PubMed: https://pubmed.ncbi.nlm.nih.gov/30170119
  13. Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, et al. Hypertrophic Cardiomyopathy in Cardiac Myosin Binding Protein-C Knockout Mice. Circ Res. 2002; 90: 594-601. PubMed: https://pubmed.ncbi.nlm.nih.gov/11909824
  14. Harris SP, Rostkova E, Gautel M, Moss RL. Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism. Circ Res.2004; 95. 930–936.
  15. Razumova MV, Bezold KL, Tu AY, Regnier M, Harris SP. Contribution of the Myosin Binding Protein C Motif to Functional Effects in Permeabilized Rat Trabeculae. JGen Physiol. 2008; 132: 575–585. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18955596
  16. Carrier L, Mearini G, Stathopoulou K, Cuello F. Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology. Gene. 2015; 573: 188-197. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660134/
  17. Harris SP, Belknap B, Van Sciver RE, White HD, Galkin VE. C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. Proc Natl Acad Sci U S A. 2016; 113: 1558-1563.
  18. Mettikolla P, Calander N, Luchowski R, Gryczynski I, Gryczynski Z, et al. Cross-bridge Kinetics in Myofibrils Containing Familial Hypertrophic Cardiomyopathy R58Q Mutation in the Regulatory Light Chain of Myosin. J Theor Biol. 2011; 284: 71-81. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152379/
  19. Lang R, Gomes AV, Zhao J, Housmans PR, Miller T, et al. Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J Biol Chem. 2002; 277: 11670-11678. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11801593
  20. Davis J, Wen H, Edwards T, Joseph M, Metzger JM. Thin Filament Disinhibition by Restrictive Cardiomyopathy Mutant R193H Troponin I Induces Ca2+-Independent Mechanical Tone and Acute Myocyte Remodeling. Circulation Res. 2007; 100: 1494–1502. PubMed: https://pubmed.ncbi.nlm.nih.gov/17463320/
  21. Davis J, Wen H, Edwards T, Joseph M, Metzger JM. Allele and Species Dependent Contractile Defects by Restrictive and Hypertrophic Cardiomyopathy-Linked Troponin I Mutants. J Mol Cell Cardiol. 2008; 44: 891-904. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18423659
  22. Du J, Liu J, Feng HZ, Hossain MM, Gobara N, et al. Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI Am J Physiol Heart Circ Physiol. 2008; 294: H2604–H2613. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769498/
  23. Zhang J, Kumar A, Stalker HJ, Virdi G, Ferrans VJ, et al. Clinical and molecular studies of a large family with desmin-associated restrictive cardiomyopathy. Clin Genet. 200; 59: 248-256.
  24. Sheng JJ, Feng HZ, Pinto JR, Wei H, Jin JP. Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction. J Mol Cell Cardiol. 2016; 99: 218–229. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26529187
  25. Parvatiyar MS, Pinto JR, Dweck D, Potter JD. Cardiac Troponin Mutations and Restrictive Cardiomyopathy. J Biomed Biotech. 2010; 350706. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896668/
  26. Jean-Charles PY, Li YJ, Nan CL, Huang XP. Monitoring Editor: Xiao Y-F. Insights into restrictive cardiomyopathy from clinical and animal studies. J Geriatr Cardiol. 2011; 8: 168–183. PubMed: https://pubmed.ncbi.nlm.nih.gov/22783303/
  27. Wen Y, Xu Y, Wang Y, Pinto JR, Potter JD, Kerrick WGL. Functional Effects of a Restrictive Cardiomyopathy linked Cardiac Troponin I mutation (R145W) in Transgenic Mice. J Mol Biol. 2009; 392: 1158–1167. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774805/
  28. Gomes AV, Liang J, Potter JD. Mutations in Human Cardiac Troponin I That Are Associated with Restrictive Cardiomyopathy Affect Basal ATPase Activity and the Calcium Sensitivity of Force Development. J Biol Chem. 2005; 280: 30909-30915. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15961398
  29. Dyer EC, Jacques AM, Hoskins AC, Ward DG, Gallon CE, et al. Functional Analysis of a Unique Troponin C Mutation, GLY159ASP, that Causes Familial Dilated Cardiomyopathy, Studied in Explanted Heart Muscle. Circulation: Heart Failure. 2009; 2: 456–464.
  30. Swindle N, Albury ANJ, Baroud B, Burney M, Svetlana B, PubMed: Molecular and Functional Consequences of Mutations in the Central Helix of Cardiac Troponin C. Arch Biochem Biophys. 2014; 548: 46–53. PubMed: https://pubmed.ncbi.nlm.nih.gov/24650606/
  31. Keller DI, Coirault C, Rau T, Cheav T, Weyand M, et al. Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties. J Mol Cell Cardiol. 2004; 36: 355-62. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440471/
  32. Kraft T, Witjas-Paalberends ER, Boontje NM, Tripathi S, Brandis A, et al Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes. J Mol Cell Cardiol. 2013; 57: 13-22. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23318932
  33. Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, et al. Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin. J Exper Biol. 2016; 219: 161-167.
  34. Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, et al. Parameters of human b-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Sci Adv. 2015; 1: e1500511.
  35. Sarkar SS, Trivedi DV, Morck MM, Adhikari AS, Pasha SN, et al. The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin Sci Adv. 2020; 6: eaax0069. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32284968
  36. Huang W, Liang J, Yuan CC, Kazmierczak K, Zhou Z, et al. Novel Familial Dilated Cardiomyopathy Mutation in MYL2 Affects the Structure and Function of Myosin Regulatory Light Chain. FEBS J. 2015; 282: 2379–2393. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472530/
  37. Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. Cardiac Dysfunction in Hypertrophic Cardiomyopathy Mutant Tropomyosin Mice Is Transgene-Dependent, Hypertrophy-Independent, and Improved by β-Blockade. Circulation Res. 2002; 91: 255–262.
  38. Michele DE, Albayya FP, Metzger JM. Direct, Convergent Hypersensitivity of Calcium-Activated Force Generation Produced by Hypertrophic Cardiomyopathy Mutant Alpha-Tropomyosins in Adult Cardiac Myocytes. Nat Med. 1999; 5: 1413-1417. PubMed: https://pubmed.ncbi.nlm.nih.gov/10581085/
  39. Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, et al. Mouse Model of a Familial Hypertrophic Cardiomyopathy Mutation in α-Tropomyosin Manifests Cardiac Dysfunction. Circ. Res 1999; 85: 47–56. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10400910
  40. Chang AN, Harada K, Ackerman MJ, Potter JD. Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin. J Biol Chem. 2005; 280: 34343-34349. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16043485
  41. Gupte TM, Haque F, Gangadharan B, Sunitha MS, Mukherjee S, et al. Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies. J Biol Chem. 2015; 290: 7003-7015. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358124/
  42. Rajan S, Ahmed RPH, Jagatheesan G, Petrashevskaya N, Boivin GP, et al. Dilated Cardiomyopathy Mutant Tropomyosin Mice Develop Cardiac Dysfunction With Significantly Decreased Fractional Shortening and Myofilament Calcium Sensitivity. Circulation Res. 2007; 101: 205–214. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17556658
  43. Song W, Dyer E, Stuckey D, Leung MC, Memo M, et al. Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J. Mol Cell Cardiol. 2010; 49: 380–389. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20600154
  44. Hernandez OM, Szczesna-Cordary D, Knollmann BC, Miller T, Bell M, et al. F110I and R278C Troponin T Mutations That Cause Familial Hypertrophic Cardiomyopathy Affect Muscle Contraction in Transgenic Mice and Reconstituted Human Cardiac Fibers. J Biol Chem. 2005; 280: 37183-37194. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16115869
  45. Morimoto S, Lu QW, Harada K, Takahashi-Yanaga F, Minakami R, et al. Ca2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy PNAS. 2002; 99: 913-918.
  46. Sfichi-Duke L, Garcia-Cazarin ML, Sumandea CA, Sievert GA, Balke CW, et al. Cardiomyopathy-causing Deletion K210 in Cardiac Troponin T Alters Phosphorylation Propensity of Sarcomeric Proteins. J Mol Cell Cardiol. 2010; 48: 934-942.
  47. Venkatraman G, Gomes AV, Kerrick WGL, Potter JD. Characterization of Troponin T Dilated Cardiomyopathy Mutationsin the Fetal Troponin Isoform. J Biol Chem. 2005; 280: 17584–17592. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15623536
  48. Jones KmD, Koh Y, Weller RS, Turna RS, Ahmad F, et al. Pathogenic Troponin T Mutants With Opposing Effects on Myofilament Ca 2+ Sensitivity Attenuate Cardiomyopathy Phenotypes in Mice. Arch Biochem Biophys. 2019; 661: 125-131. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30445044
  49. Sommese RF, Nag S, Sutton S, Miller SM, Spudich JA, et al. Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin. PLOS ONE. 2013; 8: e83403. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867432/
  50. Wolff MR, Buck SH, Stoker SW, Greaser ML, Mentzeri RM. Myofibrillar Calcium Sensitivity of Isometric Tension Is Increased in Human Dilated cardiomyopathies Role of Altered b-adrenergically Mediated Protein Phosphorylation. J Clin Invest. 1996; 98: 167–176. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8690789
  51. Lu QW, Wu XY, Morimoto S. Inherited cardiomyopathies caused by troponin mutations. J Geriatr Cardiol. 2013; 10: 91–101. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23610579
  52. de A Marques M, de Oliveira GAP. Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype. Front Physiol. 2016; 7: 429. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27721798

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Figure 1

Figure 5

Figure 1

Figure 6

Figure 1

Figure 7

Figure 1

Figure 8

Figure 1

Figure 9

Figure 1

Figure 10

Figure 1

Figure 11

Figure 1

Figure 12

Figure 1

Figure 13

Figure 1

Figure 14

Figure 1

Figure 15

Figure 1

Figure 16

Figure 1

Figure 17

Figure 1

Figure 18

Figure 1

Figure 19

Figure 1

Figure 20

Figure 1

Figure 21

Figure 1

Figure 22

Figure 1

Figure 23

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Contact

Name : Angelina Isbella

Email : angelina.I@hspcmail.us

Contact: info@hspioa.org

Journal Mail: jccm@heighpubs.us

Select by Volume & Issue

Submit Manuscript Information for Authors Advisory Board Rss Feed Articles Rss Feed

Most Viewed Keywords

University/Institution

Select and search by University/Institution.

Articles by Country

Select and search by country to get related articles.

Testmonials

I would like to thank JPRA for taking this decision. I understand the effort it represents for you. I'm truly happy to have the paper published in JPRA. And I'll certainly consider JPRA for my next publications as I was satisfied of the service provided, the efficiency and promptness of the interactions we had.

Emmanuel BUSATO

Publishing with the International Journal of Clinical and Experimental Ophthalmology was a rewarding experience as review process was thorough and brisk. Their visibility online is second to none as their published articles appear in all search engines. I will encourage researchers to publish with them.

Elizabeth Awoyesuku

“The choice to submit the forensic case study to the Journal of Addiction Therapy and Research was dictated by the match between the content and the potential readership. The publication process proved to be expedient and we were provided with constructive feedback from reviewers. The final article layout is attractive and conforms to standards. All-in-all, it has been a rewarding process.”

Elisabeth H Wiig

Archives of Vascular Medicine is one of the top class journal for vascular medicine with highly interesting topics. You did a professional and great Job!

Elias Noory

Thank you very much. I think the review process and all of what concerns the administration of the publication concerning our paper has been excellent. The nice and quick answers have been very good I think.

Doris Nilsson

Journal of Pulmonary and Respiratory Research is good journal for respiratory research purposes. It takes 2-3 weeks maximum for review of the manuscript to get published and any corrections to be made in the manuscript. It needs good articles and studies to get publish in the respiratory medicine. I am really glad that this journal editors helped me to get my case report published.

Divya Khanduja

Thanks you and your colleague for the great help for our publication. You always provide prompt responses and high quality of service. I am so happy to have you working with me. Thanks again!

Diana (Ding) Dai

Service and process were excellent as was the “look” of the article when published.

Deane Waldman

Great, thank you! It was very efficient working w/ your group. Very thorough reviews (i.e., plagiarism, peer, etc.). Would certainly recommend that future authors consider working w/ your group.

David W Brett

Your services are very good

Chukwuka Ireju Onyinye

I very much appreciate the humanitarian services provided in my stead by this journal/publisher. It exhibits total absence of editorial impertinence. As an Author, I have been guided to have a fruitful experience. The editorial care is highly commendable.

Chrysanthus Chukwuma

"An amazing experience with the Journal of Advanced Pediatrics and Child Health. Very fast blind review with pertinent corrections and suggestions. I highly recommand both the journal and the editor."

Chaimae Khairoun

The submission is very easy and the time from submission to response from the reviewers is short. Correspondence with the journal is nice and rapid.

Catrin Henriksson

The Clinical Journal of Obstetrics and Gynecology is an open access journal focused on scientific knowledge publication with emphasis laid on the fields of Gynecology and Obstetrics. Their services toward us have been encouraging through their kindness and respect. Great consideration has been given to us as young budding researchers and we are very grateful for this.

Carole Assontsa

During the process your positive communication, prompt feedback and professional approach is very highly appreciated. We would like to thank you very much for your support.

Can Vuran

I do appreciate for your service including submission, analysis, review, editorial and publishing process. I believe these esteemed journal enlighten the science with its high-quality personel.

Bora Uysal

I am very much pleased with the fast track publication by your reputed journal's editorial team. It is really helpful for researchers like me from developing nations. I strongly recommend your journal for publication.

Badri Kumar Gupta

It has been a fabulous journey writing articles for your journal because of the encouragement you people provide for writers from developing nations like India. Kindly continue the same. Looking forward for a long term association.

Badareesh Lakshminarayana

Many thanks for publishing my article in your great journal and the friendly and hassle-free publication process, the constructive peer-review, the regular feedback system, and the Quick response to any queries.

Azab Elsayed Azab

I would like to thank this journal for publishing my Research Article. Something I really appreciate about this journal is, they did not take much time from the day of Submission to the publishing date. Looking forward to have more publications in future.

Ayush Chandra

Submission of paper was smooth, the review process was fast. I had excellent communication and on time response from the editor.

Ayokunle Dada

Your service is very good and fast reply, also your service understand our situation and support us to publication our articles.

Ayman M Abu Mustafa

Really good service with prompt response. Looking forward to having long lasting relationship with your journal

Avishek Bagchi

Your service is excellent. Processing and editing were very fast. I hope to publish more of my works in your journal.

Ausraful Islam

I wanna to thank Clinical Journal of Nursing Care and Practice for its effort to review and publish my manuscript. This is reputable journal. Thank you!

Atsedemariam Andualem

“It was a delightful experience publishing my manuscript with the Clinical Journal of Obstetrics and Gynecology. They offered me lots of opportunities I never had from most publishing houses and their prompt services are greatly appreciated.”

Asafo Jones

I hope to ability to make some new investigation and publish in Your Company in future.

Artur Stopyra

I like the quality of the print & overall service. The paper looks quite impressive. Hope this will attract interested readers. All of you have our best wishes for continued success.

Arshad Khan

Your big support from researchers around the world is the best appreciation from your scientific teams. We believe that there should be no barrier in science and you make it real and this motto come true.

Arefhosseinir Rafi

Your journal co-operation is very appreciable and motivational. I am really thankful to your journal and team members for the motivation and collaboration to publish my work.

Assistant Professor, UCLAS Uttaranchal University, Dehradun, India

Archna Dhasmana

I am glad to submit the article to Heighten Science Publications as it has a very smooth and fast peer-review process, which enables the researchers to communicate their work on time.

Anupam M

This is to specify that I have had an extensive and detailed interaction with the Editorial team of Annals of Clinical Gastroenterology and Hepatology, USA, lasting over a significant period of time. My interaction has been extremely pleasant, especially with Ms Allie Smith, as I find the communication quite inspiring and crystal clear. The attitude of aforesaid individuals is quite helpful and guiding in pertinent instances. It has been a commemorative journey so far working with the Journal and I hope that the symbiosis will continue, evolve and flourish in the forthcoming years. I wish the journal, related personnel and aforementioned individuals a fruitful, successful run.

New Delhi, India

Anubha Bajaj

We appreciate the fact that you decided to give us full waiver for the applicable charges and approve the final version. You did an excellent job preparing the PDF version. Of course we will consider your magazine for our future submissions and we will pay the applicable fees then.

Anna Dionysopoulou

''Co-operation of Archives of Surgery and Clinical Research journal is appreciable. I'm impressed at the promptness of the publishing staff and the professionalism displayed. Thank you very much for your support, help and encouragement.''

Anıl Gokce

Congratulations for the excellence of your journal and high quality of its publications.

Angel MARTIN CASTELLANOS

The service from the journal staff has been excellent.

Andy Smith

I was very pleased with the quick editorial process. We are sure that our paper will have great visibility, among other things due to its open access. We believe in science accessible to all.

Anderson Fernando de Souza

It was a great experience publishing through JCICM. The article has reached out to several institutions. Appreciate your professional work. Hope to work with you again

Anas Wardeh

Publishing an article is a long process, but working with your publication department made things go smoothly, even though the process took exactly 5 months from the time of submitting the article till the time I have favourable response, the missing part is the peer review details, which is essential in self auditing and future improvement, overall experience was excellent giving your understanding of the situation of lack of financial institution support.

Anas Diab

I think that Heighpubs very good. You are very helpful. Thank you for everything.

Ana Ribeiro

Regarding to be services, we note that are work with high standards of professionalism translated into quick response, efficiency which makes communication accessible. Furthermore, I believe to be much inviting for the submission of future works for publication purposes.

Amélia João Alice Nkutxi

I would like to mention that I had a wonderful experience working with HSPI. The whole process right from manuscript submission to peer review till the publication of the article was very prompt & efficient. I wish you good luck for the future.

Amarjeet Gambhir

Once I submitted the manuscript, the response time of the reviewers was very fast. The fine-tuning of the galley proof was likewise prompt. I believe the journal provide a valuable outlet to disseminate physical rehabilitation scientific knowledge to the clinical community. Respectfully. Dr. Alon

Alon

We really appreciate and thanks the full waiver you provide for our article. We happy to publish our paper in your journal. Thank you very much for your good support and services.

Ali Abusafia

It was a real pleasure working with your team. The review was done fast, and it was very clear, the editing was flawless, the article was published quickly compared to other journals, and everyone was understanding and helpful. I will gladly recommend this journal to my acquaintances in academia.

Alexandra Cozma

To the editorial team at HSPI and the Journal of Clinical Nephrology: Thank you so much for your hard work and collaboration in bringing our article to life. Your staff was responsive, flexible, and communicative and made the process smooth and easy. Thank you!

Alejandro Munoz

Dear colleagues! I am satisfied with our cooperation with you. Your service is at a high level. I hope for a future relationship. Let me know if I can get a paper version of the magazine with my articles from you. I see them on the Internet.

Aksenov V.V

"This is my first time publishing with the journal/publisher. I am impressed at the promptness of the publishing staff and the professionalism displayed. Thank you for encouraging young researchers like me!"

Ajite Kayode

I want to thank you for our collaboration. You were fast and effective with a positive spirit of teamwork. I am truly excited from our collaboration. You were like always fast, efficient and accurate. I hope that in the near future we will collaborate again.

Aikaterini Solomou

In my opinion, you provide a very fast and practical service.

Ahmet Eroglu

Great, We are too comfortable with the process including the peer review process and quality. But, the journal should be indexed in different databases such scopus.

Afework Edmealem

We really appreciate your efforts towards our article, the professional way you handle our request for exemption from charges. It was a great honor for us to publish in your magazine.

Achraf elbakkaly

I really liked the ease of submitting my manuscript in the HSPI journal. Further, the peer review was timely completed and I was communicated the final decision on my manuscript within 10 days of submission which is really appreciable. I strongly recommend all the scientists and researchers to submit their work in this journal”

Abu Bashar

My candid opinion is that the service you render is second to none. My favourite part is the prompt response to issue, really i value that.

Abiodun Akanbi Adeogun

Thank you very much for accepting our manuscript in your journal “International Journal of Clinical Virology”. We are very thankful to the esteemed team for timely response and quick review process. The editorial team of International Journal of Clinical Virology is too cooperative and well-mannered during the publication process. We are hopeful to publish many quality papers in your journal and I suggest the International Journal of Clinical Virology to all of my colleagues, researchers and friends to publish their research here.

Abdul Baset

I, Muhammad Sarwar Khan, am serving as Editor on Archives of Biotechnology and Biomedicine (ABB). I submitted an editorial titled, 'Edible vaccines to combat Infectious Bursal Disease of poultry' for publication in ABB. After submitting the manuscript; the services rendered by the management and technical personnel to handle and process the manuscript were marvelous. Plagiarism report was shared with me with complements before reviewers' comments, All steps including article processing and service charges were well taken care of keeping in view the author's interest/preference. All together, it was an encouraging and wonderful experience working with ABB personnel.

University of Agriculture, Pakistan

Muhammad Sarwar Khan

Your journal has accomplished its intended mission of providing very effective and efficient goals in dealing with submissions, conducting the reviewing process and in publishing accepted manuscripts in a timely manner. Keep up the great work and services that you provide.

University of Jacqmar, Inc., USA

John St. Cyr

I am to express my view that Heighten Science Publications are reliable quick even after peer review process. I hope and wish the publications will go a long way in disseminating science to many interested in scientific research.

College of Fisheries, CAU(I), Tripura, India

Ajit Kumar Roy

The Journal Clinical Nephrology provides a good opportunity for readers to stay updated in the field of clinical nephrology. Additionally - it provides a good opportunity for authors to publish their work. 1. Publication of the accepted manuscripts is sufficiently rapid. 2. The trust factor between the journal and me, as an author, is very important and well preserved. 3. Peer review process very rapid and effective.

Assaf Harofeh Medical Center, Israel

Leonid Feldman

In 2017, I submitted a manuscript to the journal Archives of Biotechnology and Biomedicine belonging to Heighten Science Publications Corporation. Within one week I already received the response from the editor. All processing steps were really fast so in terms of a speedy publication I can particularly recommend the journal Archives of Biotechnology and Biomedicine. The responsible contact person of the journal was always available, which gives a trustworthy impression to the author. Also the peer review process was clear and constructive. So from my experience with Heighten Science Publications Corporation I can recommend publishing there.

University of Tubingen, Germany

Yvonne Mast

We thank to the heighten science family, who speed up the publication of our article and provide every support.

Mehmet Besir

The services of the journal were excellent. The most important thing for an author is the speed of the peer review which was really fast here. They returned in a few days and immediately replied all of my questions. I want to refer this platform to all scholars. Many thanks.

Eastern Mediterranean University, Cyprus

Zehra Guchan TOPCU

Thank you for your attitude and support. I am sincerely grateful to you and the entire staff of the magazine for the high professionalism and fast quality work. Thank you very much!

USA

Igor Klepikov

Thank you and your company for effective support of authors which are very much dependable on the funds gambling for science in the different countries of our huge and unpredictable world. We are doing our work and should rely on a teams like Galley Proof-HSPC. Great success to all of you for the 2019th! Be well all the year long.

Russia

Victor V Apollonov

The editorial process was quickly done. The galley proof was sent within a week after being accepted for publication. The editorial team was very helpful and responded promptly.

India

Rohit Kulshrestha

Publishing with the International Journal of Clinical and Experimental Ophthalmology was a rewarding experience as review process was thorough and brisk. Their visibility online is second to none as their published articles appear in all search engines. I will encourage researchers to publish with them.

University of Port Harcourt Teaching Hospital, Nigeria

Dr. Elizabeth A Awoyesuku

"It was a pleasure to work with the editorial team of the journal on the submission of the manuscript. The team was professional, fast, and to the point".

NC A&T State University, USA

Moran Sciamama-Saghiv

Submission of paper was smooth, the review process was fast. I had excellent communication and on time response from the editor.

Ekiti State University Teaching Hospital, Nigeria

Ayokunle Dada

I am delighted and satisfied with. Heighten Science Publications as my manuscript was thoroughly assessed and published on time without delay. Keep up the good work.

Ido-Ekiti/Afe Babalola University, Nigeria

Dr. Shuaib Kayode Aremu

"This is my first time publishing with the journal/publisher. I am impressed at the promptness of the publishing staff and the professionalism displayed. Thank you for encouraging young researchers like me!"

Ekiti State University, Nigeria

Adebukola Ajite

I wanna to thank clinical journal of nursing care and practice for its effort to review and publish my manuscript. This is reputable journal. Thank you!

Wollo University, Ethiopia

Atsedemariam Andualem

We appreciate your approach to scholars and will encourage you to collaborate with your organization, which includes interesting and different medical journals. With the best wishes of success, creativity and joy in life, prosperity in the medical field.

Ivano- Frankivsk National Medical University, Ukraine

Nataliya Kitsera

Thank you very much for your support and encouragement. I am truly impressed by your tolerance and support. Thank you very much

Diaverum: PADC, Jeddah, Saudi Arabia

Nasrulla Abutaleb

You are such a nice person. Your journal co-operation is very appreciable and motivational.

Department of Biotechnology, Uttaranchal college of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India

Archna Dhasmana

“Mobile apps and wearable technology are becoming ubiquitous in our environment. Their integration with healthcare delivery is just beginning to take shape. The early results are promising and the possibilities great."

BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA

Helen Figge

“The choice to submit the forensic case study to the Journal of Addiction Therapy and Research was dictated by the match between the content and the potential readership. The publication process proved to be expedient and we were provided with constructive feedback from reviewers. The final article layout is attractive and conforms to standards. All-in-all, it has been a rewarding process.”

Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA

Elisabeth H. Wiig

The service is nice and the time of processing the application is fast.

Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong

Long Ching

Your service is very good and fast reply, Also your service understand our situation and support us to publication our articles.

Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine

Ayman M Abu Mustafa

“It was a delightful experience publishing my manuscript with the Clinical Journal of Obstetrics and Gynecology. They offered me lots of opportunities I never had from most publishing houses and their prompt services are greatly appreciated.”

Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Akowuah Jones Asafo

.

View More

Related Journals

Help ?