Figure 1

Glycosaminoglycans as Novel Targets for in vivo Contrast-Enhanced Magnetic Resonance Imaging of Atherosclerosis

Yavuz O Uca* and Matthias Taupitz

Published: 20 April, 2020 | Volume 5 - Issue 1 | Pages: 080-088

jccm-aid1091-g001

Figure 1:

Atherosclerotic plaque progression. The native endothelium maintains vascular homeostasis (A). Early atherogenesis is characterized by the formation of the neointima through lipid influx, monocyte transmigration and foam cells (B). Persisting inflammation during atherosclerotic plaque progression leads to formation of lipid cores. Arterial remodeling results in increased vasa vasorum activity forming neovessels. In parallel, medial smooth muscle cells undergo phenotypic changes and migrate into the neointima. Here, they proliferate and produce new extracellular matrix molecules forming the fibrous cap. Tissue breakdown and thinning of the fibrous cap provoke erosion and renders the plaque vulnerable by inducing tears, intraplaque hemorrhage and thrombosis (C,D) [19,38].

Read Full Article HTML DOI: 10.29328/journal.jccm.1001091 Cite this Article Read Full Article PDF

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