Published: 20 April, 2020 | Volume 5 - Issue 1 | Pages: 080-088
Figure 4:
Schematic illustration of different glycosaminoglycan interactions. Glycosaminoglycans localize, stabilize, activate or inactivate proteins [98]. Decorin is a proteoglycan form of dermatan sulfate, which binds to collagen (A). Heparin interacts with fibronectin (B) [133]. Monocyte transmigration happen through interactions with the cell surface heparan sulfates on the endothelium and glycosaminoglycan low density lipoprotein complexes are more easily internalized by macrophages than lipoproteins alone (C) [101,127]. Glycosaminoglycans serve as storage reservoir for chemokines (D) and growth factors (F) [128]. They perform the highest affinity binding by inducing conformational changes and surface complementarity on the proteins [111,112]. Heparan sulfate-fibroblast growth factor and heparin anti thrombin III are the most well-known examples for such interactions (E).
Read Full Article HTML DOI: 10.29328/journal.jccm.1001091 Cite this Article Read Full Article PDF
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