Study to Evaluate the Safety, Efficacy, and Duration of Dual Antiplatelet Therapy in Coronary Artery Disease Patients

Main Article Content

Aashritha Mary Dodda
Oggu Archana
Shiksha Netam
Bommagani Pavan Kumar
Emani Sai Sri Jayanthi

Abstract

Coronary artery disease (CAD) is a leading cause of mortality globally, characterized by the formation of atherosclerotic plaques that impede blood flow to the myocardium. Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 inhibitor, is essential for reducing ischemic events post-coronary stenting. This paper aimed to evaluate the safety, efficacy, and optimal duration of DAPT with ECOSPRIN+TICAGRELOR versus ECOSPRIN+CLOPIDOGREL in CAD patients.

Article Details

Mary Dodda, A., Oggu Archana, Shiksha Netam, Bommagani Pavan Kumar, & Emani Sai Sri Jayanthi. (2025). Study to Evaluate the Safety, Efficacy, and Duration of Dual Antiplatelet Therapy in Coronary Artery Disease Patients. Journal of Cardiology and Cardiovascular Medicine, 10(2), 022–027. https://doi.org/10.29328/journal.jccm.1001206
Prospectives

Copyright (c) 2025 Dodda AM, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

1. Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA. 2007;297(18):2018-24. Available from: https://doi.org/10.1001/jama.297.18.2018

2. Kaushansky K. Determinants of platelet number and regulation of thrombopoiesis. Hematology Am Soc Hematol Educ Program. 2009:147-52. Available from: https://doi.org/10.1182/asheducation-2009.1.147

3. Rocca B, Secchiero P, Ciabattoni G, Ranelletti FO, Catani L, Guidotti L, et al. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A. 2002;99(11):7634-9. Available from: https://doi.org/10.1073/pnas.112202999

4. Lindemann S, Tolley ND, Dixon DA, McIntyre TM, Prescott SM, Zimmerman GA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol. 2001;154(3):485-90. Available from: https://doi.org/10.1083/jcb.200105058

5. Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018;137(12): e67-e492. Available from: https://doi.org/10.1161/cir.0000000000000558

6. WHO-World Health Organization; Geneva: 2016. Global Health Estimates 2015: Deaths by Cause, Age, Sex, by Country and by Region, 2000–2015.

7. Hermanson B, Omenn GS, Kronmal RA, Gersh BJ. Beneficial six-year outcome of smoking cessation in older men and women with coronary artery disease. Results from the CASS registry. N Engl J Med. 1988;319(21):1365-9. Available from: https://doi.org/10.1056/nejm198811243192101

8. Nakahara T, Dweck MR, Narula N, Pisapia D, Narula J, Strauss HW. Coronary Artery Calcification: From Mechanism to Molecular Imaging. JACC Cardiovasc Imaging. 2017;10(5):582-593. Available from: https://doi.org/10.1016/j.jcmg.2017.03.005