Research activities are focused on identifying mechanisms responsible for obesity associated metabolic diseaes with a view of developing preventive and treatment strategies for these disorders including Type-2 diabetes mellitus and cardiovascular diseases. Obesity leads to a chronic low-grade inflammation in the adipose tissue, which is in part responsible for the development of whole-body insulin resistance. The major focus of our research program is to uncover these mechanisms. We are also interested in identifying the reasons as to why individuals of Asian origin are at a higher risk of developing cardiovascular disease compared to Caucasians at a given body mass index. Research areas include adipose tissue inflammation, systemic insulin resistance and clinical aspects of bariatric surgery. We employ in vivo as well as in vitro systems, with a spectrum of cellular and molecular biology techniques coupled with studies of whole-animal physiology to address important questions in the above areas of research.
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