Figure 1

Influence of Histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats

Victor Tsirkin*, Alexander Nozdrachev, Julia Korotaeva and Grigorij Khodyrev

Published: 19 November, 2018 | Volume 3 - Issue 3 | Pages: 084-103

jccm-aid1030-g001

Figure 1:

Mechanogramms - caused by electrostimulation (1 Hz, 5 ms, 20 V) contractions of myocardial strips
of right ventricle of nonpregnant rats (Phase metaestrus; panels A, C and D) and pregnant rat (17 day; panel B) in steps 1-8 of series III (panel A), of series V (panel B), of series VII (panel C) and in steps 1-4 series VIII (panel D). Mechanograms demonstrate the ability of histidine (10-4 g/mL, His 4) to restore the effectiveness of the activation of beta-adrenoceptors (AR), which reduced by propranolol (10-8 g/mL, Pr8; panel A), or by atenolol (10-8 g/mL, At8; panel B) or by nicergoline (10-8 g/mL, N8; panel C), and the absence of histidine effect against the backdrop of the joint effects of nicergoline (10-8 g/mL), and propranolol (10-8 g/mL, panel D). KS - Krebs solution; Ad5 - adrenaline, 10-5 g / mL; сalibration - 4 mN, 3 min.

Read Full Article HTML DOI: 10.29328/journal.jccm.1001030 Cite this Article Read Full Article PDF

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